![]() ![]() Laboratory analysis: elevated LDH and liver transaminases.Specificity of ∼ 100%, sensitivity of 85%.within the first 1–2 weeks after symptom onset) and antibodies have not developed yet. In some cases, the test can show negative results if it is performed too soon (i.e.No heterophile antibodies present → no cross-reaction → no agglutination.Positive test: cross-reaction between heterophile antibodies and sheep/horse RBCs → agglutination.Patient's serum is mixed with a solution of sheep/horse RBC in vitro.Detects h eterophile antibodies p roduced in response to EBV infection using RBCs from sheep or horses.Although complications are rare, IM is associated with atraumatic splenic rupture due to splenomegaly and multiple malignancies (e.g., Hodgkin's lymphoma, Burkitt lymphoma).Ĭlinical suspicion of IM is confirmed via antibody testing. IM is treated symptomatically, as it is usually self-limiting. Patients exhibit lymphocytosis, often with atypical T lymphocytes on a peripheral smear. To avoid misdiagnosis, suspected cases are confirmed with a heterophile antibody test ( monospot test), or in some cases, positive serology. ![]() IM is also sometimes associated with a measles-like exanthem, especially in individuals who are falsely diagnosed with bacterial tonsillitis and given ampicillin or amoxicillin. Symptomatic individuals typically first experience fever, malaise, and fatigue, which is later accompanied by acute pharyngitis, tonsillitis, lymphadenopathy, and/or splenomegaly lasting up to a month. Infection frequently goes unnoticed in children mainly adolescents and young adults exhibit symptoms. The disease is highly contagious and spreads via bodily secretions, especially saliva. ![]() Infectious mononucleosis (IM), also called "mono" or the "kissing disease", is an acute condition caused by the Epstein-Barr virus ( EBV). ![]()
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